With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of th

Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseas

Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the t

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials.

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest an