Harnessing Dendritic Cells to Promote Immune Tolerance

Download or read book Harnessing Dendritic Cells to Promote Immune Tolerance written by and published by . This book was released on 2013 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Allergen-specific immunotherapy (SIT) is considered to be the sole curative therapeutic approach of mono allergies. However, the widespread use of SIT is hindered by the small but imminent risk of developing anaphylactic reactions. Another major drawback of SIT is the relatively low efficacy reflected by the long treatment duration. The work described in this thesis aims at establishing the foundations for novel efficacious modalities of SIT. Since the development of immune tolerance mediated by regulatory T (Treg) cells is an essential element for successful SIT, this study focused on the use of regulatory adjuvants, compounds that via their effect on antigen-presenting dendritic cells (DCs) promote the development of Treg cells."--Samenvatting auteur.