Molecular Mechanisms of Dendritic Cell-Mediated Immune Tolerance and Autoimmunity

Download or read book Molecular Mechanisms of Dendritic Cell-Mediated Immune Tolerance and Autoimmunity written by Fang Zhou and published by Frontiers Media SA. This book was released on 2024-04-09 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.