Advances in Mechanisms of Renal Fibrosis
Author | : Hui Y. Lan |
Publisher | : Frontiers Media SA |
Total Pages | : 84 |
Release | : 2018-07-26 |
ISBN-10 | : 9782889454990 |
ISBN-13 | : 2889454991 |
Rating | : 4/5 (991 Downloads) |
Download or read book Advances in Mechanisms of Renal Fibrosis written by Hui Y. Lan and published by Frontiers Media SA. This book was released on 2018-07-26 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.