Ubiquitination and Sumoylation are two important posttranslational modifications that play pivotal roles in a variety of biological functions. Although Ubiquiti

DNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the delet

Most proteins undergo post-translational modifications altering physical and chemical properties, folding, conformation distribution, stability, activity and fu

A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in