Molecular Mechanisms of Estrogen and Antiestrogen Resistance

Download or read book Molecular Mechanisms of Estrogen and Antiestrogen Resistance written by and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an Academic (Career Development) Award. Consistent with this award, the PI continues to ". appraise critically the state of the science in a particular aspect of breast cancer research and to forge new avenues of investigation." In this application, the studies are focused on antiestrogen resistance. With respect to the career development aspects, several original studies and reviews relevant to this application have been published, others have been submitted for publication. We continue to apply state-of-the- art technologies to addressing resistance, including the development of novel approaches to data mining and analysis. The studies of interferon regulatory factor-1 (IRF-1) continue. We have now completed the initial studies of the IRF-1 dominant negative IRF-1 construct. Immunohistologic methods for correlative studies on human breast tissues for nucleophosmin, NFxB, IRF-1 and X-box binding protein -1 (hXBP-1) have been completed on an initial study population. Several applications for funding arising directly from these studies have been submitted to NIH and DOD.