Regulation of Endothelial Barrier Function

Regulation of Endothelial Barrier Function
Author :
Publisher : Biota Publishing
Total Pages : 160
Release :
ISBN-10 : 9781615041213
ISBN-13 : 1615041214
Rating : 4/5 (214 Downloads)

Book Synopsis Regulation of Endothelial Barrier Function by : Sarah Y. Yuan

Download or read book Regulation of Endothelial Barrier Function written by Sarah Y. Yuan and published by Biota Publishing. This book was released on 2011-02-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood–tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell–cell and cell–matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care.


Regulation of Endothelial Barrier Function Related Books

Regulation of Endothelial Barrier Function
Language: en
Pages: 160
Authors: Sarah Y. Yuan
Categories: Medical
Type: BOOK - Published: 2011-02-01 - Publisher: Biota Publishing

DOWNLOAD EBOOK

The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the
Inflammation and the Microcirculation
Language: en
Pages: 99
Authors: D. Neil Granger
Categories: Medical
Type: BOOK - Published: 2010 - Publisher: Morgan & Claypool Publishers

DOWNLOAD EBOOK

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillari
The Endothelium
Language: en
Pages: 309
Authors: Michel Félétou
Categories: Science
Type: BOOK - Published: 2011 - Publisher: Morgan & Claypool Publishers

DOWNLOAD EBOOK

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphati
The Vascular Endothelium I
Language: en
Pages: 344
Authors: Salvador Moncada
Categories: Medical
Type: BOOK - Published: 2006-12-22 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by exp
Capillary Fluid Exchange
Language: en
Pages: 86
Authors: Joshua Scallan
Categories: Science
Type: BOOK - Published: 2010 - Publisher: Morgan & Claypool Publishers

DOWNLOAD EBOOK

The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular wa